Will the ovulation injection have any effect on the fetus?

After trying to conceive for several months, prospective parents still haven't gotten pregnant. They start to consider taking ovulation-stimulating injections, but they are worried that it will affect the fetus in the future. So will taking ovulation-stimulating injections have an impact on the fetus? What are the side effects of taking ovulation-stimulating injections?

What is ovulation induction injection

The ovulation-stimulating injection contains two gonadotropins, FSH and LH, which can help the development and maturation of follicles and promote their secretion of estrogen. However, LSH plays the main role, while LH plays a very small role. If the pituitary gland and ovaries still have a certain function, estrogen will be produced. Estrogen will indirectly act on the pituitary gland through positive feedback, prompting it to secrete sufficient LH, thereby promoting ovulation. If the pituitary gland is not functioning properly, it is necessary to continue to use chorionic gonadotropin to promote ovulation while maintaining the function of the corpus luteum.

Will the ovulation injection have any effect on the fetus?

Experts say that embryos are formed by the combination of male sperm and female eggs. The existence of eggs is inherent in women, and about one egg is discharged during each menstruation. If the discharge is normal, conception is possible. Ovulation drugs only add an external force to the discharge process, and have no effect on the egg itself, nor will they damage the egg, and will not affect the fertilized egg or the child born.

How to inject ovulation

From the third to the fifth day of menstruation or withdrawal bleeding, women are given an intramuscular injection of ovulation-promoting needles, two per day, for seven consecutive days. Each needle contains FSH75 and LH75 units, which are dissolved into 1-2 ml by sodium chloride injection. During this period, the condition of the follicles should be monitored by B-ultrasound. When the follicles reach 20mm and the urine estrogen reaches 100-200ug within 24 hours, 5000-10000 units of HCG are injected on the last day to promote ovulation. For women who still do not get pregnant, two cycles of treatment can be repeated.

If the urine estrogen content exceeds 200ug within 24 hours, it is not suitable to continue using HCG to prevent excessive stimulation. If ovulation still does not occur, the injection volume should be increased to 3-4 injections per day under the monitoring of urine estrogen or B-ultrasound. The treatment time for most patients should not exceed 10 days. If only FSH is used, the initial injection volume should be 150 units, once a day.

For the treatment of male hypopituitarism, 75 or 50 units of FSH and 75 or 150 units of LH are injected intramuscularly 3 times a week to stimulate spermatogenesis. There are reports of stillbirth and congenital malformations in pregnancy after the combined treatment of this product with chorionic gonadotropin, but it has not been proven to be directly related to this product. This product is not the first choice of ovulation-inducing drug for the treatment of anovulation. It can be used for patients who are ineffective for other ovulation-inducing drugs (including clomiphene) and those who do not ovulate due to hypogonadism. The dosage should be determined according to the clinical response of each individual.

During the treatment with this product, when the follicles are mature, the diameter of the follicles is more than 20mm by ultrasound examination, and the estrogen content reaches 100-150ug in 24 hours, chorionic gonadotropin can be injected. If the above indicators are exceeded, symptoms of ovarian hyperstimulation appear and the drug should be discontinued. Patients with ovarian cysts or enlarged ovaries should not use this product because they may continue to grow.

Side effects of ovulation injections

High estrogen levels

Ovulation-stimulating drugs act on the hypothalamus, cutting off the feedback effect of estrogen on it, causing the estrogen level in the body to increase, making it easy to suffer from ovarian hyperstimulation syndrome, leading to endocrine disorders, water and electrolyte imbalance, pelvic and abdominal effusions, and even blood clots. Excessive secretion of estrogen may also cause breast tumors and ovarian cysts to grow faster.

Cause other complications

Ovulation-stimulating drugs can cause a sudden increase in ovarian ovulation. Normal people cannot tolerate this change and it can also cause other complications, such as ovarian cysts or even rupture, embolism, electrolyte imbalance, ovarian hyperstimulation syndrome, etc. It can also increase the burden on the liver and kidneys, leading to liver and kidney failure, pleural effusion, and severe cases can cause shock and amputation in pregnant women.

Pregnancy complications caused by multiple births

Multiple births can cause pregnancy complications, not only increasing the chances of premature birth and miscarriage, but also increasing the burden on the heart, liver and kidneys of pregnant women. During childbirth, most pregnant women will experience heavy bleeding, DIC (disseminated intravascular coagulation), heart failure, and even shock.