Can I have IVF if I have chromosomal abnormalities? Can I have children if I have chromosomal abnormalities?

Chromosomal abnormalities between husband and wife are undoubtedly a big blow to a family. It directly determines whether or not you can have children. So can you have children with chromosomal abnormalities? Can you do IVF with chromosomal abnormalities? Let's find out together~

Can I have children if I have chromosomal abnormalities?

Chromosomal abnormality is a disease that causes fertility problems for patients. It usually occurs during pregnancy. If the child is maldeveloped during the fetal period, they may die, or if they are deformed during pregnancy, these may be caused by chromosomal abnormalities. Therefore, patients with chromosomal abnormalities should pay attention to them. If these situations occur, they should go to the hospital for examination. These may seriously affect the ability of the baby and may also cause other effects on the child. So, can chromosomal abnormalities lead to childbirth?

1. In fact, chromosomal abnormalities generally come from parents and have little effect on fertility. However, some chromosomal abnormalities may also affect the development of the fetus and are related to the chromosomal abnormalities of the fetus itself. It is uncertain, and the reasons why the embryo stops developing are also very complicated.

2. Patients with chromosomal abnormalities may have children with poor development during pregnancy, or they may die in the fetal period, or fail in pregnancy, which may also cause the child to have developmental deformities. Therefore, patients with chromosomal abnormalities should pay attention.

3. For patients with chromosomal abnormalities, there is a chance to give birth to a normal baby, but there is also the possibility of giving birth to a deformed baby. For patients with chromosomal abnormalities, it is better to go to the hospital for treatment before getting pregnant, so as to avoid affecting the fetus.

Note: Patients with chromosomal abnormalities are generally not recommended to have children, because chromosomal problems may mean there is a problem with the genetic genes, and the child may be abnormal, so it is recommended not to have children. These may also affect the child's future and have a great impact on the child.

Can I have IVF if I have chromosomal abnormalities?

There are many reasons for infertility in couples, such as major problems with the woman's fallopian tubes, ovaries, uterus, eggs, etc., or major problems with the man's sperm. But there is a deeper reason that is often ignored by infertile patients, that is, chromosomal abnormalities. Generally speaking, chromosomal abnormalities will cause diseases, such as Down syndrome, autism, Klinefelter's disease, etc., and such chromosomal abnormalities have a high probability of being inherited. So for patients with chromosomal abnormalities, can they do IVF and get their own healthy baby through IVF?

Chromosomes are very important cells. They are the main carriers of genetic material DNA. Chromosomes appear in pairs. Each pair of chromosomes will separate from each other during meiosis, and then enter different daughter cells. The separated chromosomes can be freely combined. Chromosomes carry genes, and genes determine the development of our organs and the development of the human body. However, many times, chromosomes will be abnormal during division. Chromosome abnormalities are usually manifested as chromosome deletion, translocation, increase in number, duplication, triploidy, etc.

Chromosomal abnormality, a word that seems strange and far away from us. But in fact, chromosomal abnormality is not rare. About one in every 500 people may have chromosomal translocation. Moreover, chromosomal abnormality has no gender difference. Both men and women may have chromosomal abnormality.

Patients with chromosomal abnormalities are likely to pass on their diseases to the next generation, causing the next generation to also suffer from chromosomal abnormalities. Therefore, patients who know that they have chromosomal abnormalities must not have children through natural pregnancy. If patients with chromosomal abnormalities want to have their own children, they can use in vitro fertilization technology to greatly reduce the incidence of the disease in their offspring.

So how can people with chromosomal diseases give birth to healthy children? It is recommended that you use IVF technology to get your own healthy baby. Can IVF technology really allow people with chromosomal abnormalities to have healthy babies? The answer is yes.

When people with the same chromosomes undergo IVF, they must undergo a genetic screening called the third-generation IVF PGD/PGS technology. Through this technology, problematic embryos can be screened out, which avoids the occurrence of unhealthy babies in the mother.

Preimplantation genetic diagnosis (PGD) is the most common genetic testing term and is an umbrella term for any kind of genetic testing you hear done on an embryo. The term PGD has become popular among geneticists, reproductive endocrinologists, and most lay publications because it refers to testing an embryo before it is implanted.

Initially, PGD was developed in the late 1980s to help high-risk couples avoid passing on major genetic diseases to their offspring. Instead of terminating a pregnancy if a genetic disorder was found during prenatal testing, couples could use IVF to fertilize the fertilized egg and test the embryo before implantation.

Causes of Chromosomal Abnormalities

1. Physical factors: The radiation environment in which humans live, including natural radiation and artificial radiation. Long-term exposure to radiation environment and radiation X-rays can cause chromosomal abnormalities.

2. Chemical factors: People are exposed to various chemical substances in daily life, some of which are natural products and some are artificially synthesized. They can enter the human body through diet, breathing or skin contact, and cause chromosomal abnormalities.

3. Biological factors: When cells in culture are treated with viruses, various types of chromosomal aberrations often occur, including breakage, fragmentation, and exchange.

4. Maternal age effect: When the fetus is 6-7 months old, all oogonia have developed into primary oocytes and entered the nuclear reticulation stage from the first meiotic prophase. At this time, the chromosomes are loose and stretched again, just like the previous nucleus, and they remain until before ovulation in adolescence. With the increase of maternal age, under the influence of many factors inside and outside the mother, the egg may also undergo many aging changes, affecting the relationship between the same pair of chromosomes in mature division and the action in the late division, which leads to non-disjunction between chromosomes.

5. Genetic factors: passed down from the father or mother, that is, inherited.

6. Autoimmune diseases: Autoimmune diseases seem to play a role in chromosome nondisjunction. For example, there is a close correlation between increased primary thyroid autoimmune antibodies and familial chromosomal abnormalities.

Can chromosomal abnormalities be cured?

Chromosomal abnormalities are difficult to treat and the results are unsatisfactory. There is no effective medicine to treat the congenital intellectual disability caused by them. You can try traditional Chinese medicine treatment and rehabilitation training.

Prenatal care

The prognosis of different types of chromosomal dysplasia varies, and most have a poor prognosis. Mental retardation and growth retardation are common characteristics of chromosomal diseases. Chromosomal dysplasia is difficult to treat and the effect is unsatisfactory. Prevention is more important. Preventive measures include promoting genetic counseling, chromosome testing, prenatal diagnosis and selective abortion to prevent the birth of affected children. Pregnant women should have regular prenatal examinations so that if there is a problem with the fetus, it can at least be discovered early. Amniocentesis is one of the methods to test whether the fetus has congenital chromosomal defects.