How many days does it take for IVF to implant? The specific process of IVF

IVF is a life-saving straw for infertile couples. How many days does it take for IVF to implant? What are the procedures for IVF? Is IVF good? You will understand after reading this article~

How many days after IVF implantation

The time of fertilized egg implantation needs to be combined with your own situation. It usually takes about 3-4 days after transplantation. A few implantations are later, and there are certain individual differences. At the same time, about 14 days after the embryo transfer, it is recommended that you go to the hospital for examination to confirm whether you are pregnant. If you have any questions, you can contact the doctor for further information.

The specific process of IVF

1. Controlled superovulation: Since the length of the natural menstrual cycle varies from person to person, and there are also differences in different cycles for the same patient, it is not easy to arrange the time for egg retrieval. In addition, only one dominant follicle develops in the natural cycle, and only one embryo can be formed after fertilization, and the pregnancy rate of transplanting one embryo is very low. Therefore, controlled superovulation is needed to enhance and improve ovarian function, so as to achieve the purpose of not being restricted by the natural cycle, obtaining multiple healthy eggs, providing multiple embryo transplants, and synchronizing the development of the corpus luteum with the function of the endometrium as much as possible. Controlled superovulation generally uses GnRHa to downregulate FSH and LH in the body, and then administers HMG or FSH ovulation drugs to stimulate the growth of follicles in the ovaries. The dosage of the drug is adjusted according to the patient's responsiveness to the drug.

2. Monitoring follicles: To evaluate the effect of ovarian stimulation and determine the time of egg retrieval, vaginal B-ultrasound is required to monitor the size of follicles, and blood tests are conducted to check the E2 value (estrogen) to adjust the dosage. When two to three or more follicles are larger than 1.8 cm in diameter, and the number of follicles larger than 1.4 cm is equivalent to the E2 value, human chorionic gonadotropin (hCG) can be injected to promote follicle maturation. Eggs are retrieved 34 to 36 hours after hCG injection.

3. Egg retrieval: The most commonly used method of egg retrieval is to insert the egg retrieval needle through the vaginal vault and directly reach the ovary to absorb the eggs under local anesthesia and then immediately transfer the eggs to a culture dish containing embryo culture medium under a microscope and culture them in a 37°C incubator.

4. Sperm collection: The time of sperm collection is the same day as the day of egg collection. Wash your hands before sperm collection and use masturbation to collect semen. The small cup provided is sterile. Do not touch the edge of the cup or the inside of the cup when collecting. The semen collected is processed by swim-up method or Percoll density gradient centrifugation.

5. In vitro fertilization: 4-5 hours after egg retrieval, place the processed sperm and eggs in the same culture dish and culture them together for 18 hours. The fertilization can be observed under a microscope. If the sperm quality is too poor to allow natural fertilization, microinjection must be used to force fertilization.

6. Embryo culture in vitro.

7. Embryo transplant.

8. Supplement progesterone after embryo transfer.

9. Test morning urine on the 14th day after embryo transfer to determine whether you are pregnant.

10. 14 days after pregnancy, B-ultrasound is performed to check the number of fetuses and the site of embryo implantation.

Six common misconceptions about IVF

1. Test-tube babies will be mentally retarded or disabled

This is also another major psychological barrier for infertile couples to refuse IVF. In particular, an article was published some time ago reporting that the IQ of babies is lower than that of naturally conceived babies, which has caused doubts among many infertile couples. In fact, after more than 20 years of development, hundreds of thousands of babies have been born worldwide. The early use of this technology also gave birth to normal babies. Some larger-scale follow-up surveys and studies have confirmed that there is no significant difference between IVF babies and naturally conceived babies in terms of birth defects and subsequent physical and intellectual development. Infertile couples can rest assured.

2. Taking ovulation-stimulating injections can make people fat

Some patients complain that they gain weight after taking the ovulation injection. This phenomenon is because the ovulation injection will increase the estrogen level, causing water to be retained in the body (i.e. temporary "water retention"), leading to weight gain or edema. After a period of treatment, as the drug is metabolized, the estrogen level returns to normal, the retained water in the body will be discharged, and the weight and edema will be restored. Some women, fearing that diet and activity will affect their success rate, will over-supplement and limit physical activity, or even stay in bed every day, which will naturally cause fat accumulation and weight gain.

3. Test tube babies are prone to miscarriage

Long-term follow-up results from reproductive medicine centers in different countries over the years have confirmed that the rates of early miscarriage and fetal malformation in IVF are similar to those in natural conception. In addition, if you choose to do a third-generation IVF, that is, the chromosome screening of the embryo is performed, the miscarriage rate after pregnancy will be reduced to less than 5%, and the health risks of the fetus will also be greatly reduced, which can better achieve eugenics!

4. IVF has a low success rate and is very expensive

Many infertile couples seeking medical treatment are concerned about the success rate and fees when applying for this technology. The success rate of this technology was indeed low in the early days, below 10%, but with the advancement of science, the technology has become increasingly mature and the success rate has continued to increase. At present, the success rate of large medical institutions in China that have been carrying out this technology for a long time and have rich experience has reached about 40%, close to the international advanced level. This success rate does not mean that only 40 out of 100 couples who undergo this technology can succeed, but only means that there may be 40 chances of success in 100 operations, which is much higher than the probability of a normal couple getting pregnant during sexual intercourse. The average probability of a normal couple getting pregnant during sexual intercourse is about 5-6 ovulation cycles, which is about 20%. As for the fees, each hospital charges differently.

5. Test-tube babies are not biological children

This is the biggest misunderstanding. Many couples seeking medical treatment do not accept IVF. A big psychological barrier is that they mistakenly believe that the technology is "artificially manufactured" for them by the hospital using medical methods, or that the hospital uses eggs from the egg bank and sperm from the sperm bank to cultivate them, not their own flesh and blood. In fact, most of this technology is cultivated with eggs and sperm from both spouses, and the hospital cannot have so many surplus eggs and sperm. Unless the couple seeking medical treatment has no eggs (such as premature ovarian failure) or no sperm (such as azoospermia), and applies to the hospital to provide eggs or sperm. Of course, this technology is not "artificially manufactured" by the hospital using medical materials.

6. IVF increases the risk of breast cancer

In recent years, there have been some false reports that ovulation induction may increase the risk of cancer, and there have also been gossip news saying that a certain celebrity had breast cancer because she had done multiple IVFs. In fact, breast cancer mainly occurs in women who carry the breast cancer gene. In addition, bad living habits can also increase the risk of disease. Like the normal population, some patients who undergo IVF may also develop breast cancer. The results of a large sample study by Swedish scientists show that the risk of cervical carcinoma in situ and breast cancer in women who undergo IVF is lower than that of the normal population, so IVF itself does not increase the risk of breast cancer.

"No. 5 Parenting" (:yuer5h)