Which has a higher success rate, frozen embryo or fresh embryo? What are the advantages and disadvantages of frozen embryo and fresh embryo transplantation?

We have all heard of frozen embryos. Many female celebrities will take out their embryos in advance and freeze them, just in case. So for IVF, which one has a higher success rate, frozen embryos or fresh embryos? What are the advantages and disadvantages of frozen embryo and fresh embryo transplantation?

What is fresh embryo transfer

During IVF treatment, a fresh embryo transfer is performed shortly after egg retrieval. Fresh embryo transfer can occur from the first to the sixth day after successful fertilization.

Advantages: If you don’t pay attention to these, do you still want to have a boy?

Shorten the overall IVF treatment time (if it is successful). For those patients who have been eager to get pregnant for a long time, the fresh embryo transfer will be performed soon after the egg retrieval, which can shorten the treatment time.

shortcoming:

1. Ovulation-inducing drugs can cause hormone levels to rise. Ovulation-inducing drugs taken during treatment can cause hormone levels in the body to rise. If the amount of fertility hormones does not reach normal levels, fresh embryo transfer will bring more difficulties in the future. I was infertile for six years, but I got pregnant in one month after using this trick.

2. The endometrium's acceptance rate for transplanted embryos is reduced. Some evidence suggests that excessive estrogen may reduce the endometrium's acceptance rate for transplanted embryos, making it difficult for the embryo to implant.

What is frozen embryo transfer

Embryos are frozen and stored, and then transplanted after thawing is called frozen embryo transplant.

advantage:

1. Avoid or reduce delayed ovarian hyperstimulation syndrome (OHSS). Patients have a higher incidence of ovarian hyperstimulation syndrome during the egg retrieval and transplantation process. After the ovaries are stimulated by hormones, excess human chorionic gonadotropin can induce OHSS. Although the condition is usually mild, OHSS can cause cysts and stimulate the production of large amounts of hormones, such as estrogen, progesterone, and cytokines. Some rare and extreme cases may be dangerous to the patient and the fetus. Frozen embryo transfer can effectively reduce or avoid this situation. A big PK of secrets to having a boy, this one ranks first

2. The endometrium has a higher acceptance rate for frozen embryos: When the patient's uterus is better repaired and recovered, the success rate of transplantation will be greatly increased.

3. Leave more time for complex genetic testing. If the patient hopes to use preimplantation genetic diagnosis (PGD) or preimplantation genetic screening (PGS) to determine the most suitable healthy embryo for transplantation, frozen embryo transplantation can reserve more time for testing. [Getting pregnant] These 7 manifestations, seize the opportunity to have a baby!

shortcoming:

Compared with fresh embryo transfer, frozen embryo transfer requires a longer waiting time before pregnancy can be achieved. Even for fresh embryo transfer, the waiting time is long for a family eager for a baby. Waiting for another month for frozen embryo transfer seems to be even more tormenting.

Which has a higher success rate, frozen embryos or fresh embryos?

Many couples who are doing IVF don’t know whether to choose frozen embryos or fresh embryos. There are reports that the success rate of frozen embryos is higher than that of fresh embryos. Is this true?

1. One egg retrieval for multiple uses

During the IVF treatment, one or more embryos (up to more than ten) are often obtained. In addition to the first transplant, the remaining embryos can be thawed and used for the second transplant, or for re-transplantation after the first IVF transplantation fails. This can save treatment costs more than re-stimulation. Of course, we hope that the transplantation will be successful in one go.

2. Freezing can actually increase the success rate

Some scholars have conducted experiments and found that the successful pregnancy rate is 78% when all embryos are frozen and thawed and then implanted, and the successful pregnancy rate is 50.9% when freshly implanted embryos. The success rate of implanting thawed embryos is higher than that of implanting fresh embryos.

Why freezing embryos can improve the success rate

The success rate of pregnancy of freshly implanted embryos is low. Some of the more common reasons are that when the ovulation injection is used to induce ovulation, the estrogen in the female body rises to a level beyond the physiological high concentration, and the progesterone that induces ovulation also rises a lot.

Studies have shown that when a woman's endometrium is affected by the increase of these abnormal factors, it will mature prematurely and not develop synchronously with the embryo. When the freshly implanted embryo implants, the endometrium may have passed the stage where it is suitable for implantation. Therefore, the success rate of pregnancy with a freshly implanted embryo is lower.

3. Embryo culture recovery is very important

Although the success rate of IVF with implanted thawed embryos is high, the blastocyst culture requires high conditions and high technical requirements for doctors. First of all, the embryo operation technician must have good embryo freezing technology. In this process, it can be ensured that the embryo will not be harmed during each freezing and thawing process, and that each process is perfect and harmless to the embryo. Secondly, the doctor must have professional medical skills and find the right time to implant the thawed embryo, so that the transplantation is more in line with the physiological implantation time, so as to achieve synchronization with the endometrium to improve the clinical pregnancy rate and embryo implantation rate.

There is not much difference between frozen embryos and fresh embryos

1. From the perspective of embryos. There is no difference between frozen embryos and fresh embryos. After the embryos are frozen, as long as they can survive and continue to develop after thawing, there is no problem. Frozen embryos will only be damaged during the thawing process, and embryos damaged by thawing cannot be transplanted. Therefore, the fetus of a frozen embryo transplant will not be affected in any way.

2. From the patient's perspective. Some female friends will have temporary endocrine disorders for a short period of time after ovulation induction, which will not only make the female uterus not synchronized with the development of the embryo, but also affect the success rate of IVF. However, frozen embryo transplantation can be done after the drug reaction disappears, or even slowly wait for the female's body to adjust. In this case, the success rate of frozen embryo transplantation is actually higher.

The laboratory equipment and embryo environment of the IVF hospital are very important. Its hardware facilities need to be in line with international standards. The advanced laboratory equipment is an important material condition to ensure in vitro fertilization. Good embryos come from good eggs, good sperm and a stable laboratory culture system. In fact, it is the technical experts and operators on the software, such as embryo implantation surgery: It is one of the important parts for the success of IVF. Properly placing the embryo in a position that is easy to implant can easily increase the success rate. It is also critical for the doctor to master the IVF implantation window. The doctor's specific implementation plan and assisted hatching technique, the timing of implantation in the embryonic stage or blastocyst stage, and the methods and steps to improve embryo implantation all determine the success or failure of the IVF operation.

Frozen embryo transfer is a very important technology in IVF. The selected IVF hospital must have embryo freezing and thawing technology. During the thawing process of frozen embryos, if the IVF hospital's technology is not enough, it will cause more embryo loss than experienced hospitals, resulting in the death of many lives. Therefore, you must carefully choose an IVF hospital, and choose an authoritative, reliable, and regular IVF hospital.